Cytogenetics Laboratory
The Michigan State University Clinical Cytogenetics Laboratory offers a full range of cytogenetic testing. Established in 1969, the MSU Cytogenetics Laboratory has built a solid reputation by providing service of the highest caliber. Services include: timely processing of samples, direct, personalized reporting of results, availability of preliminary reports, professional staff, including board certified genetic counselors, competitive fees, and arranged specimen transportation.
The MSU Cytogenetics Laboratory employs a multidisciplinary team of highly trained, experienced professionals including cytogenetic technologists certified by the National Certification Agency (NCA).
Dr. Sainan Wei is the director of the DNA Diagnostic Program and the Cytogenetics Laboratory. Dr. Wei received a Ph.D. in Genetics and an M.S. in Epidemiology from MSU. She then completed a fellowship in clinical molecular genetics and clinical cytogenetics at Henry Ford Hospital and is Board Certified in both.
The MSU Cytogenetics Laboratory is dedicated to providing high-quality, cost-effective patient care. To ensure this standard, we are fully accredited under CLIA/CAP guidelines, participate in several proficiency programs, and follow the guidelines for cytogenetic laboratory testing prescribed by the American College of Medical Genetics. In addition, the MSU Cytogenetics Laboratory is accredited by the Children’s Oncology Group.
The MSU Cytogenetics Laboratory uses state-of-the-art cytogenetic technologies. We employ specialized cell culture techniques, such as in-situ cover-slip methods, to obtain high quality mitotic images. Karyotypes are produced using an advanced computerized karyotyping system. MSU Cytogenetics has also incorporated FISH (florescent in-situ hybridization) technology. FISH can be useful in identifying subtle chromosome changes often unobservable with standard chromosome analysis. FISH is especially useful in identifying submicroscopic rearrangements associated with certain types of cancer and for diagnosing specific microdeletion and microduplication syndromes. Prenatal detection of trisomy 13, 18, 21, and sex chromosome aneuploidy is possible within 24-48 hours using FISH on uncultured amniotic fluid.
A telephone and/or faxed report is made on all amniocentesis, newborn and oncology cases. The written report includes an analysis and interpretation of the findings, as well as an original karyotype. Genetic counseling regarding abnormal test results or evaluation for further diagnostic evaluation is available through our clinical genetics team. View the test panel.
DNA Diagnostic Program
Since 1993, the DNA Diagnostic Program has been dedicated to providing quality genetic testing at a reasonable cost. We strive to make available the most recent information regarding the tests we offer, and we are currently expanding our services.
Dr. Sainan Wei is the director of the DNA Diagnostic Program and the Cytogenetics Laboratory (see above).
Dr. John Gerlach, who is board certified in Histo-Compatibility and Immuno-Genetics (DABHI), continues to provide support to the DNA Diagnostic Program. The laboratory staff also includes a board certified genetic counselor and laboratory technicians, all of whom are available to assist you with questions regarding our laboratory services.
The DNA Diagnostic Program provides individualized test interpretations and risk estimations based on test results, ethnic background and family history. Abnormal results are promptly called to the referring physician's office. Final reports are sent by mail and/or fax. View our test panel.
Prenatal Screening Program
The MSU Prenatal Screening Laboratory was established in 1982 under the direction of Dr. Rachel Fisher. Since that time, laboratory services have expanded to include the most up to date first trimester and second trimester screening and diagnostic tests available for Down syndrome, neural tube defects, trisomy 18 and Smith-Lemli-Opitz (SLOS) syndrome. The MSU Prenatal Screening Laboratory provides maternal serum screening services for patients throughout the state of Michigan. The laboratory is also actively involved in research.
The MSU Prenatal Screening Laboratory is part of a comprehensive screening program that includes genetic counselors and laboratory personnel who communicate positive test results directly to the physician and provide assistance in coordinating follow-up and diagnostic studies. Genetic counselors are available to answer questions from physicians and patients regarding test results. Educational brochures regarding screening options are available for physicians and patients.
Two new screening tests available through the MSU Prenatal Screening Laboratory utilize Fetal Nuchal Translucency measurements. The fetal NT is an ultrasound measurement of the amount of fluid behind the baby’s neck. Babies with large measurements are at an increased risk for several birth defects, including heart defects. Fetal NT measurements can be combined with maternal serum markers for increased detection of Down syndrome and trisomy 18 (Full Integrated Test) or earlier detection of Down syndrome and trisomy 18 (First Trimester Test).
An ultrasonographer certified to perform NT measurements for screening is available through the MSU Department of Radiology. Certified ultrasonographers have attended a course and passed a practical examination as recommended by the Fetal Medicine Foundation and the Maternal Fetal Medicine Foundation. The MSU Prenatal Screening Laboratory participates in the MFMF’s Nuchal Translucency Quality Review Program. View our test panel.