Department of Pediatrics and Human Development
College of Human Medicine

André S. Bachmann, PhD
Professor; Associate Chair for Research
301 Michigan Street NE, Office 514
616-331-5982
This email address is being protected from spambots. You need JavaScript enabled to view it.

PubMed




Bachmann Lab August 2016 1André S. Bachmann, Professor with tenure in the College of Human Medicine's Department of Pediatrics and Human Development, studies the therapeutic potential of polyamine and proteasome inhibitors in cancer patients. Much of his research has provided new insights into neuroblastoma and other pediatric cancers. Dr. Bachmann's ongoing study of ornithine decarboxylase (ODC) -- a protein often overexpressed in cancer -- has shown ODC inhibitor DFMO induces death in neuroblastoma cancer cells (Oncogene, 2005). In collaboration with Helen DeVos Childrens' Hospital pediatric oncologist Dr. Giselle Sholler and the Neuroblastoma and Medulloblastoma Translational  Research Consortium (NMTRC), Dr. Bachmann has advanced his research of DFMO through a phase I clinical trial (PLoS One, 2015), to an ongoing phase II clinical trial with neuroblastoma patients.

Also of interest to the Bachmann Lab are the molecular mechanisms of proteasome-mediated cell death in neuroblastoma and multiple myeloma, and the discovery of novel, natural-product-based proteasome inhibitors. In collaboration with colleagues in Europe, Dr. Bachmann in part discovered the syrbactin class of proteasome inhibitors (Nature, 2008), for which he holds a U.S. patent. His lab also studies the 4TM protein PRAF2, which has prognostic value in neuroblastoma (Clinical Cancer Research, 2007).

 

Education & Training

MS, Microbiology, University of Zürich/ETH Zürich, Switzerland, 1994
PhD, Biology, University of Zürich, Switzerland 1998
Postdoctoral Fellow, Molecular Oncology & Virology, University of Zürich, Switzerland, 1998-1999

 

Selected Grants

R01, National Cancer Institute (NCI), NIH
Wipe Out Kids Cancer (WOKC)
ARRA Grant, National Cancer Institute (NCI), NIH
R43, National Institute of Allergy and Infectious Disease (NIAID), NIH
Hawaii Community Foundation (HCF)
Magic Water Foundation
Weinman Foundation

 

Selected Peer-Reviewed Publications

Oncogene, 2005, 24(36):5606-18
Clinical Cancer Research, 2007, 13(21):6312-9
Cancer Research, 2008, 68(23):9825-31
Nature, 2008, 452(7188):755-8
Molecular Cancer Therapeutics, 2009, 8(7):2067-75
PNAS, 2009, 106(16):6507-12
International Journal of Cancer, 2010, 126(9):2012-24
Cancer Science, 2010, 101(7):1624-31
Biochemistry, 2012, 51(34):6880-8
Journal of Molecular Biology, 2014, 426(2):332-46
Cellular Oncology, 2014, 37(6):387-98
PLoS One, 2015, 10(5):e0127246
BMC Cancer, 2015, 15:477
Journal of Biological Chemistry, 2016, 291:8350-62

 

Awards & Honors

Swiss National Science Foundation Award, 1994
Siemens National Mentor Award, 2007
Inaugural Weinman Award for Translational Research, 2010

 

Lab Directory

André Bachmann, PhD
André Bachmann, PhD
Professor and Principal Investigator
This email address is being protected from spambots. You need JavaScript enabled to view it.

Chad Schultz, BS
Chad Schultz, BS
Research Assistant II
This email address is being protected from spambots. You need JavaScript enabled to view it.

Marie Mooney, PhD
Marie Mooney, PhD
Postdoctoral Researcher
This email address is being protected from spambots. You need JavaScript enabled to view it.

Marquicia Pierce, PhD
Marquicia Pierce, PhD
Industrial Postdoctoral Researcher
This email address is being protected from spambots. You need JavaScript enabled to view it.

Rebecca Weicht-Graves, DO
Rebecca Weicht-Graves, DO
Clinical Fellow (Pediatric Oncology)
This email address is being protected from spambots. You need JavaScript enabled to view it.

Katie Uhl, MS
Katie Uhl, MS
Research Assistant I
This email address is being protected from spambots. You need JavaScript enabled to view it.